Cosmeceutical peptides have become an important topic in recent decades in both\nacademic and industrial fields. Many natural or synthetic peptides with different biological\nfunctions including anti-ageing, anti-oxidation, anti-infection and anti-pigmentation have been\ndeveloped and commercialized. Current cosmeceutical peptides have already satisfied most market\ndemand, remaining: â??cargos carrying skin penetrating peptide with high safetyâ? still an un-met\nneed. To this aim, a cell-penetrating peptide, CPPAIF, which efficiently transported cargos into\nepithelial cells was exanimated. CPPAIF was evaluated with cell model and 3D skin model following\nOECD guidelines without using animal models. As a highly stable peptide, CPPAIF neither irritated\nnor sensitized skin, also did not disrupt skin barrier. In addition, such high safety peptide had antiinflammation\nactivity without allergic effect. Moreover, cargo carrying activity of CPPAIF was\nassayed using HaCaT cell model and rapid CPPAIF penetration was observed within 30 min. Finally,\nCPPAIF possessed transepidermal activity in water in oil formulation without disruption of skin\nbarrier. All evidences indicated that CPPAIF was an ideal choice for skin penetrating and its antiinflammatory\nactivity could improve skin condition, which made CPPAIF suitable and attractive for\nnovel cosmeceutical product development.
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